Hannah Payne's life has been devoted to church and family, but after her arrest, she awakens to a nightmare: she is lying on a table in a bare room, covered only by a paper gown, with cameras broadcasting her every move to millions at home, for whom observing new Chromes—criminals whose skin color has been genetically altered to match the class of their crime—is a new and sinister form of entertainment. Hannah is a Red; her crime is murder. The victim, according to the State of Texas, was her unborn child, and Hannah is determined to protect the identity of the father, a public figure with whom she's shared a fierce and forbidden love.

When She Woke is a fable about a stigmatized woman struggling to navigate an America of a not-too-distant future—where the line between church and state has been eradicated and convicted felons are no longer imprisoned and rehabilitated but chromed and released back into the population to survive as best they can. In seeking a path to safety in an alien and hostile world, Hannah unknowingly embarks on a path of self-discovery that forces her to question the values she once held true and the righteousness of a country that politicizes faith.